Journal article
Characterization of the role of etallothionein-3 in an animal model of Alzheimer's disease
Y Manso, J Carrasco, G Comes, G Meloni, PA Adlard, AI Bush, M Vašák, J Hidalgo
Cellular and Molecular Life Sciences | SPRINGER BASEL AG | Published : 2012
Abstract
Among the dementias, Alzheimer's disease (AD) is the most commonly diagnosed, but there are still no effective drugs available for its treatment. It has been suggested that metallothionein-3 (MT-3) could be somehow involved in the etiology of AD, and in fact very promising results have been found in in vitro studies, but the role of MT-3 in vivo needs further analysis. In this study, we analyzed the role of MT-3 in a mouse model of AD, Tg2576 mice, which overexpress human Amyloid Precursor Protein (hAPP) with the Swedish mutation. MT-3 deficiency partially rescued the APP-induced mortality of females, and mildly affected APP-induced changes in behavior assessed in the hole-board and plus-maz..
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Grants
Awarded by Australian Research Council
Funding Acknowledgements
The authors are grateful for grants from the Ministerio de Ciencia e Innovacion y Cofinanciada por el Fondo Europeo de Desarrollo Regional (FEDER), SAF2002-01268, SAF2005-00671, SAF2008-00435, and SAF2011-23272 (J.H.). Y.M. acknowledges her Ph.D. fellowship (AP2005-0588). P. A. is supported by the National Health and Medical Research Council of Australia, The Australian Research Council, The Alzheimer's Association (USA), and the Joan and Peter Clemenger Trust. A. B. is a paid consultant and shareholder of Prana Biotechnology Ltd, and a paid consultant of Adenoa Inc, and a shareholder of Brighton Biotech Inc. P. A is a paid consultant and shareholder of Prana Biotechnology Ltd.